Just use the high strength loctite. I've used it I'm my rock crawler that I'm sure sees much more abuse than any titan on the road. Safety wire is a pain to install anyway.
2008.5 Titan CC LE FFV, rear drop, k&n cai, flowmaster 50 series, 5% tint, all emblems removed, Two POLK audio 12s
2012 m37s (wife's)
1989 Mustang GT,408w,AFR 205,Edelbrock Supervic EFI, Pro-m 80. Yup it's fast.